Dating origin ccr5 delta32

10-Oct-2020 18:29

Sangamo specializes in developing enzymes called zinc finger nucleases that can bind to genes, clip their DNA, and repair mutations (, 23 December 2005, p. But for the HIV gene therapy, they’ve created a nuclease to specifically disrupt the CCR5 gene in the same manner as the natural mutation.

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Researchers discovered in 1996 that people who had a naturally occurring mutation in their genes for one of these, CCR5, were strongly protected from developing AIDS—or even becoming infected in the first place—and suffered no ill effects from lacking the receptor.

Because binding to CD4 alone can sometimes result in gp120 shedding, gp120 must next bind to co-receptor CCR5 in order for fusion to proceed.