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The first drug in the SSRI class was Prozac (Fluoxetine), which hit the United States market in 1987. Luvox (Fluvoxamine maleate) was the next SSRI FDA approved in December 05, 1994.However, now its marketing status is "Discontinued". 6) Prozac-least (most energizing) how baout zoloft, luvox, lexapro, etc? The only SSRI I've been on is Paxil CR 25mg and I don't find it sedating at all.Based on "Essential Psychopharmacology" written by Stephen M.The strategy behind rational drug development is to design a new drug that is capable of affecting a specific neural site of action (e.g., uptake pumps, receptors) while avoiding effects on other site of actions.The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications.
SSRIs seem to relieve symptoms of depression by blocking the reabsorption (reuptake) of serotonin by certain nerve cells in the brain.
This leaves more serotonin available, which enhances neurotransmission and improves mood.
SSRIs are called selective because they seem to affect serotonin significantly more than other neurotransmitters.
Stahl, MD, Ph D by e Med Expert staff Medical references reviewed: August, 2018 The most significant class of antidepressants marketed in recent years is the selective serotonin reuptake inhibitors (SSRIs).
The six SSRIs available in the United States are: The SSRIs represent the first rationally designed class of psychotropic medications.
Lexapro (Escitalopram oxalate) is the newest and most selective of the SSRIs approved by the FDA in August 14, 2002. The brain communicates with itself through the use of special chemicals called neurotransmitters, such as serotonin and norepinephrine.